Carbon-hydrogen bond activation or CH activation.may be defined as a reaction that cleaves a carbon-hydrogen bond. Often the term is restricted to reactions involving organometallic complexes and proceeding by coordination of a hydrocarbon to the inner-sphere of metal, either via an intermediate “alkane or arene complex” or as a transition state leading to a M-C intermediate.[1][2] [3] Important to this definition is the requirement that during the CH cleavage event the hydrocarbyl species remains associated in the inner-sphere and under the influence of “M”.
Theoretical studies as well as experimental investigations indicate that CH bonds, which are traditionally considered unreactive, can be cleaved by coordination. Much research effort has been devoted to the design and synthesis of new reagents and catalysts that can affect CH activation. A significant driver for this type of research is the prospect that C-H activation could enable the conversion of cheap and abundant alkanes into valuable functionalized organic compounds
No comments:
Post a Comment